So what actually makes it hard to drive a W125?
The only thing I can imagine is the total lack of power steering - making the steering itself heavy. What else is so physically tiring about driving those cars?
well for starters they were probably a lot less balanced overall than modern technology would allow. They also used manual gearboxes, which require more force to operate, depressing the heavy clutch multiple times per lap and having to manually adjust for engine speed etc. In a modern car the driver never has to take his hands off the steering wheel. The centre of gravity was much, much higher than in today's cars and the brakes wouldn't have been anywhere near as powerful or reliable, either. Look at the amount of steering correction a driver today has to do even compared with drivers of 20 years ago, then imagine that increasing the further you go into the past as technology and understanding of car behaviour worsens.