Like I said before, I'm not terribly fond of tubular spaceframe construction. It uses cheap stock material, it's easy to design and repair but that's about it. Its stiffness/weight ratio is inferior to that of either aluminum extrusions or aluminum honeycomb. It requires skilled labor(ers) to fabricate, not to mention a jig etc... And despite all of that, tolerances for chassis pickup points etc.. are usually no better than 3-4mm compared to 0.5mm for bonded aluminum. Big difference...
So there is no doubt in my mind that I would rather use a bonded aluminum chassis of some sort.
But there are a few questions I need answered before I can commit any ideas to paper. Firstly,
what are the pros and cons of bonded extrusions compared to bonded aluminum honeycomb? Why would one use one in place of the other? I would imagine that honeycomb would be more expensive, but would be stiffer and lighter yet... I'm also guessing a combination of both would be best? Like honeycomb for the bulkheads and extrusions for the "frame rails"? Any books or references on the matter would be highly appreciated.
Secondly there's the matter of economics. How much more expensive would extrusions and/or honeycomb construction be compared to a tubular steel spaceframe? With the former and please feel free to correct me at any point, you've got an expensive raw material, but a cheap manufacturing process (less labour intensive, easier and faster to make) whereas with the latter, raw material is (significantly) cheaper, but production is slower and more labour intensive. To sum up, approximately how much more expensive would a bonded aluminum chassis be?
Then there's the issue of durability, safety, and ease of repair.
Regarding durability, I'd like to bring up a good point imaginesix brought up,
With regards to the frame, I must point also out that Lotus were unable to adapt the bonded unibody concept to the engine/gearbox/rear suspension cradle of the Elise, because there were too many mounting points that needed to be located in close proximity, that caused insurmountable structural problems. The engine bay for the Elise is a steel spaceframe bolted to the aluminium 'tub'.
I would imagine that this would be more of a problem on the mid-engined Elise, with its more cramped engine/transmission layout, and their proximity to a multitude of mounting points. I don't think would be as much of a problem for my setup (FR remember) , especially if I were to ceramic coat the headers and not install catalytic converters

Safety should be at least as good if not better than a similar steel chassis, and if I were to design in replaceable front, rear, and side impact modules (a la Panoz Esperante) the chassis should be very easy to repair in the event of a prang!
That's pretty much it I guess, I'd like to hear your opinions on this, see if there's anything I left out or didn't cover...